Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewNQ 301
说明： Selective CD45 inhibitor
化学名： 2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione
纯度： ≥98% (HPLC)
生物活性 for NQ 301
NQ 301 is a selective CD45 inhibitor (IC50 = 200 nM). Exhibits >200-fold selectivity for CD45 over six related protein tyrosine phosphatases. Increases phosphorylation of Lck in Jurkat cells and reduces T cell receptor signaling in acitvated splenocytes in vitro. Blocks inflammation in a delayed-type hypersensitivity model in vivo.
技术数据 for NQ 301
| 分子量 | 325.75 |
| 公式 | C18H12ClNO3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 130089-98-4 |
| PubChem ID | 781109 |
| InChI Key | LSQZKIQSQHZVQS-UHFFFAOYSA-N |
| Smiles | O=C1C(Cl)=C(NC2=CC=C(C(C)=O)C=C2)C(C3=CC=CC=C31)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NQ 301
参考文献 for NQ 301
参考文献是支持产品生物活性的出版物。
Perron et al (2014) Allosteric noncompetitive small molecule selective inhibitors of CD45 tyrosine phosphatase suppress T-cell receptor signals and inflammation in vivo. Mol.Pharmacol. 85 553 PMID: 24473749
按产品操作查看相关产品
关键词: NQ 301, NQ 301 supplier, NQ301, selective, CD45, protein, tyrosine, phosphatase, PTP, inhibitors, inhibits, potent, leukocyte, common, antigen, LCA, Protein, Tyrosine, Phosphatases, 5724, Tocris Bioscience
NQ 301 的评论
目前没有该产品的评论。 Be the first to review NQ 301 and earn rewards!
Have you used NQ 301?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image