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NS 3728

Cat. No. 6973 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： VRAC blocker
别名： Endovion
化学名： N-[3,5-bis(Trifluoromethyl)phenyl]-N'-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]urea
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NS 3728

NS 3728 is a volume-regulated anion channel (VRAC) blocker (IC50 = 460 nM). Blocks red blood cell chloride conductance (IC50 = 0.6 μM). NS 3728 also inhibits Ca2+-activated Cl- current (CaCC) by anoctamin (ANO) in an apparently voltage-dependent manner (IC50 against ANO1 = 2.1 and 0.7 μM at -95 and +50 mV, respectively).

技术数据 for NS 3728

分子量 495.18
公式 C16H9BrF6N6O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 265646-85-3
PubChem ID 10005966
InChI Key AEFYFGMSRKDXHZ-UHFFFAOYSA-N
Smiles FC(F)(C1=CC(C(F)(F)F)=CC(NC(NC2=C(C3=NN=NN3)C=C(C=C2)Br)=O)=C1)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NS 3728

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 49.52 100
ethanol 24.76 50

制备储备液 for NS 3728

以下数据基于产品分子量 495.18。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.1 mL 20.19 mL
5 mM 0.4 mL 2.02 mL 4.04 mL
10 mM 0.2 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for NS 3728

参考文献是支持产品生物活性的出版物。

Helix et al (2003) Inhibition of the endogenous volume-regulated anion channel (VRAC) in HEK293 cells by acidic di-aryl-ureas. J.Membr.Biol. 196 83 PMID: 14724745

Kjaer et al (2009) Chloride channel blockers inhibit iNOS expression and NO production in IFNgamma-stimulated microglial BV2 cells. Brain Res. 1281 24 PMID: 19446535

Godwin et al (2019) E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function. Gastric Cancer 22 273 PMID: 30066183

Sauter et al (2015) ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC). Pflugers Arch. 467 1495 PMID: 25163766

If you know of a relevant reference for NS 3728, please let us know.

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关键词: NS 3728, NS 3728 supplier, NS3728, volume-regulated, anion, channel, VRAC, blockers, Endovion, Other, Chloride, Channels, 6973, Tocris Bioscience

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