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Submit ReviewNS 3763
说明： GluK1 selective and non-competitive kainate antagonist
化学名： 4,6-Bis(benzoylamino)-1,3-benzenedicarboxylic acid
纯度： ≥98% (HPLC)
生物活性 for NS 3763
Selective non-competitive kainate receptor antagonist; displays selectivity for GluK1 (formerly GLUK5) subunit-containing receptors (IC50 values are 1.6 and > 30 μM for homomeric GluK1 (formerly GLUK5) and GluK2 (formerly GLUK6) receptors respectively). Has minimal activity at AMPA and NMDA receptors (IC50> 30 μM).
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
技术数据 for NS 3763
| 分子量 | 404.38 |
| 公式 | C22H16N2O6 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 70553-45-6 |
| PubChem ID | 4359312 |
| InChI Key | UUDYZUDTQPLDDP-UHFFFAOYSA-N |
| Smiles | O=C(C2=CC=CC=C2)NC1=CC(NC(C3=CC=CC=C3)=O)=C(C(O)=O)C=C1C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NS 3763
参考文献 for NS 3763
参考文献是支持产品生物活性的出版物。
Christensen et al (2004) In vitro characterization of 5-carboxyl-2,4-di-benzamido-benzoic acid (NS3763), a noncompetitive antagonist of GLUK5 receptors. J.Pharmacol.Exp.Ther. 309 1003 PMID: 14985418
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关键词: NS 3763, NS 3763 supplier, Selective, non-competitive, kainate, antagonists, selective, GLUK5, Glutamate, Kainate, Receptors, iGluR, Ionotropic, NS3763, GluK1, 2187, Tocris Bioscience
NS 3763 的评论
平均评分: 4 (Based on 1 Review.)
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NS 3763 was studied to determine its NMDA effect:Product works well and the results publishable.
By
Sadequl Islam on 10/12/2018
分析类型： In Vitro
种属： Human
NS 3763 performed extremely well when tested for NMDA activity. The correlation of NS 3763 was studied in respect to its effect with NMDA regulation.
The NS 3763 cannot be dissolved in aqueous media and must be dissolved in DMSO. For sterile conditions/study, sterile DMSO is mandatory.
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