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NS 383

Cat. No. 5927 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： ASIC blocker; active in vivo
化学名： 8-Ethyl-6,7,8,9-tetrahydro-5-phenyl-1H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-oxime
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NS 383

NS 383 is an ASIC blocker (IC50 values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3). Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.

技术数据 for NS 383

分子量 321.37
公式 C19H19N3O2
储存 Store at -20°C
CAS Number 309711-59-9
PubChem ID 135418391
InChI Key CHVQAXYXYIDNDC-UHFFFAOYSA-N
Smiles CCN1CCC2=C(C3=C(/C(C(N3)=O)=N\O)C=C2C4=CC=CC=C4)C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NS 383

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 1.61 5

制备储备液 for NS 383

以下数据基于产品分子量 321.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.05 mM 62.23 mL 311.17 mL 622.34 mL
0.25 mM 12.45 mL 62.23 mL 124.47 mL
0.5 mM 6.22 mL 31.12 mL 62.23 mL
2.5 mM 1.24 mL 6.22 mL 12.45 mL

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参考文献 for NS 383

参考文献是支持产品生物活性的出版物。

Munro et al (2016) NS383 Selectively inhibits acid-sensing ion channels containing 1a and 3 subunits to reverse inflammatory and neuropathic hyperalgesia in rats. CNS Neurosci.Ther. 22 135 PMID: 26663905

If you know of a relevant reference for NS 383, please let us know.

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关键词: NS 383, NS 383 supplier, NS383, ASIC, blockers, acid-sensing, ion, channels, inflammatory, pain, Voltage-gated, Sodium, Channels, 5927, Tocris Bioscience

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