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NSC 95397

Cat. No. 1547 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1547 has been discontinued.

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说明： Selective Cdc25 dual specificity phosphatase inhibitor
化学名： 2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone
纯度： ≥97% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for NSC 95397

NSC 95397 is a potent and selective irreversible inhibitor of Cdc25 dual specificity phosphatases (Ki values are 32, 96 and 40 nM for inhibition of Cdc25A, -B and -C respectively). Displays 125 - 180-fold selectivity over VH1-related dual-specificity phosphatase and protein tyrosine phosphatase 1b. Inhibits carcinoma cell growth and blocks G2/M phase transition in vitro.

技术数据 for NSC 95397

分子量 310.38
公式 C14H14O4S2
储存 Desiccate at -20°C
纯度 ≥97% (HPLC)
CAS Number 93718-83-3
PubChem ID 262093
InChI Key MAASHDQFQDDECQ-UHFFFAOYSA-N
Smiles OCCSC1=C(SCCO)C(=O)C2=CC=CC=C2C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for NSC 95397

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for NSC 95397

参考文献是支持产品生物活性的出版物。

Han et al (2004) NAD(P)H:Quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors. J.Pharmacol.Exp.Ther. 309 64 PMID: 14718602

Lazo et al (2002) Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors. Mol.Pharmacol. 61 720 PMID: 11901209

Melchheier et al (2005) Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation. Biochem.Biophys.Res.Commun. 327 1016 PMID: 15652497

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关键词: NSC 95397, NSC 95397 supplier, Selective, Cdc25, dual, specificity, phosphatases, inhibitors, inhibits, NSC95397, Phosphatase, 1547, Tocris Bioscience

1 篇 NSC 95397 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NSC 95397 的部分引用包括：

Dulyaninova et al (2011) Cysteine 81 is critical for the interaction of S100A4 and myosin-IIA. Biochemistry 50 7218 PMID: 21749055

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