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NU 2058

Cat. No. 3135 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3135 has been discontinued.

View all CDK1 Subfamily (CDK1, CDK2 & CDK3) products.
说明： Cdk1 and cdk2 inhibitor
化学名： 6-(Cyclohexylmethoxy)-9H-purin-2-amine
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for NU 2058

NU 2058 is a cyclin-dependent kinase (cdk) 1 and cdk2 inhibitor (Ki values are 5 and 12 μM respectively). Inhibits growth of human tumor cells in vitro (mean GI50 = 13 μM). Also inhibits DNA topoisomerase II ATPase activity (IC50 = 300 μM).

技术数据 for NU 2058

分子量 247.3
公式 C12H17N5O
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 161058-83-9
PubChem ID 4564
InChI Key MWGXGTJJAOZBNW-UHFFFAOYSA-N
Smiles NC1=NC(OCC3CCCCC3)=C2C(NC=N2)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for NU 2058

参考文献是支持产品生物活性的出版物。

Arris et al (2000) Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles. J.Med.Chem. 43 2797 PMID: 10956187

Knockaert et al (2002) Pharmacological inhibitors of cyclin-dependent kinases. TiPS 23 417 PMID: 12237154

Jensen et al (2005) Substituted purine analogues define a novel structural class of catalytic topoisomerase II inhibitors. Cancer Res. 65 7470 PMID: 16103101

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关键词: NU 2058, NU 2058 supplier, Cdk1, cdk2, Topoisomerase, II, inhibits, inhibitors, Cyclin-Dependent, Protein, Kinases, DNA, Isomerases, NU2058, Cyclin-dependent, Kinase, CDK1, Subfamily, 3135, Tocris Bioscience

1 篇 NU 2058 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NU 2058 的部分引用包括：

Goonesekere et al (2014) A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers. PLoS One 9 e93046 PMID: 24740004

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