NVP 2

Cat. No. 6535 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective ATP-competitive CDK9 inhibitor

化学名： 4-[[[5'-Chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile

纯度： ≥97% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for NVP 2

NVP 2 is a potent and selective ATP-competitive CDK9 inhibitor (IC₅₀ = 0.5 nM). Exhibits selectivity for CDK9 over a panel of 468 kinases, but inhibits DYRK1B (IC₅₀ = 350 nM), displays <90% binding to CDK7 (IC₅₀ >10 μM) and CDK13. Inhibits proliferation of MOLT4 cells in vitro. Induces apoptosis.

技术数据 for NVP 2

分子量	513.07
公式	C₂₇H₃₇ClN₆O₂
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	1263373-43-8
PubChem ID	66937006
InChI Key	XWQVQSXLXAXOPJ-QNGMFEMESA-N
Smiles	COC[C@H](N[C@H]1CC[C@H](NC2=CC(C3=NC(NCC4(C#N)CCOCC4)=CC=C3)=C(C=N2)Cl)CC1)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NVP 2

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	51.31	100
	ethanol	51.31	100

制备储备液 for NVP 2

以下数据基于产品分子量 513.07。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.95 mL	9.75 mL	19.49 mL
5 mM	0.39 mL	1.95 mL	3.9 mL
10 mM	0.19 mL	0.97 mL	1.95 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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产品说明书 for NVP 2

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NVP 2

参考文献是支持产品生物活性的出版物。

Olson et al (2018) Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat.Chem.Biol. 14 163 PMID: 29251720

Winter et al (2017) BET bromodomain proteins function as master transcription elongation factors independent of CDK9 recruitment. Mol.Cell 67 5 PMID: 28673542

If you know of a relevant reference for NVP 2, please let us know.

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关键词: NVP 2, NVP 2 supplier, NVP2, Cyclin-dependent, protein, kinases, inhibitors, inhibits, Cdk9, potent, selective, Kinase, Transcriptional, CDKs, 6535, Tocris Bioscience