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NVS-STG2

Cat. No. 8120 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： STING agonist, molecular glue that causes oligomerization of STING
化学名： 4-((4-(2-(tert-Butyl)-5,5-dimethyl-1,3-dioxan-2-yl)benzyl)amino)-3-methoxybenzoic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NVS-STG2

NVS-STG2 is a STING agonist. It induces oligomerization of human STING by binding to pockets between adjacent STING dimer transmembrane domains, acting as a molecular glue. NVS-STG2 elicits potent STING-mediated immune responses in cells and produces antitumor activities in hSTING knock-in mice.

技术数据 for NVS-STG2

分子量 427.54
公式 C25H33NO5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 3030588-01-0
PubChem ID 168719774
InChI Key CZSPKEVHLRWAFC-UHFFFAOYSA-N
Smiles OC(C1=CC=C(C(OC)=C1)NCC2=CC=C(C=C2)C3(OCC(C)(CO3)C)C(C)(C)C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NVS-STG2

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 42.75 100

制备储备液 for NVS-STG2

以下数据基于产品分子量 427.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.34 mL 11.69 mL 23.39 mL
5 mM 0.47 mL 2.34 mL 4.68 mL
10 mM 0.23 mL 1.17 mL 2.34 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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参考文献 for NVS-STG2

参考文献是支持产品生物活性的出版物。

Li et al (2024) Activation of human STING by a molecular glue-like compound. Nat.Chem.Biol. 20 365 PMID: 37828400

If you know of a relevant reference for NVS-STG2, please let us know.

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关键词: NVS-STG2, NVS-STG2 supplier, Sting, agonists, transmembrane, domains, oligomerization, activation, human, STING, pathway, in, vivo, NVSSTG2, antitumor, molecular, glue, STING-Dependent, Signaling, Molecular, Glues, 8120, Tocris Bioscience

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