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Submit ReviewNXY 059
说明： Free radical trapping agent; neuroprotectant
化学名： 4-[[(1,1-Dimethylethyl)oxoimino]methyl]-1,3-benzenedisulfonic acid disodium salt
纯度： ≥98% (HPLC)
生物活性 for NXY 059
NXY 059 is a free radical trapping agent. Reduces infarct size and preserves brain function in several animal models of acute ischemic stroke. Neuroprotectant.
技术数据 for NXY 059
| 分子量 | 381.33 |
| 公式 | C11H13NNa2O7S2 |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 168021-79-2 |
| PubChem ID | 6440181 |
| InChI Key | XLZOVRYBVCMCGL-BPNVQINPSA-L |
| Smiles | [Na+].[Na+].CC(C)(C)[N+](\[O-])=C\C1=C(C=C(C=C1)S([O-])(=O)=O)S([O-])(=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NXY 059
参考文献 for NXY 059
参考文献是支持产品生物活性的出版物。
Peeling et al (2001) Efficacy of disodium 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (NXY-059), a free radical trapping agent, in a rat model of hemorrhagic stroke. Neuropharmacology 40 433 PMID: 11166336
Sydserff et al (2002) Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window. Br.J.Pharmacol. 135 103 PMID: 11786485
Culot et al (2009) Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: an in vitro study. Brain Res. 1294 144 PMID: 19631615
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关键词: NXY 059, NXY 059 supplier, Free, radical, trapping, agent, neuroprotectant, scavenger, NXY059, Antioxidants, 3645, Tocris Bioscience
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