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说明： Inhibitor of anandamide uptake
化学名： N-(bis-3-chloro-4-hydroxybenzyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
生物活性 for O-2093
O-2093 is an inhibitor of anandamide uptake (IC50 = 17.3 μM) with little or no activity at CB1, CB2, TRPV1 and FAAH. Intravenous administration inhibits limb spasticity in mice with chronic relapsing experimental allergic encephalomyelitis (CREAE).
许可信息
Sold under license from VCU-IPF
技术数据 for O-2093
| 分子量 | 584.62 |
| 公式 | C34H43Cl2NO3 |
| 储存 | Desiccate at -20°C |
| CAS Number | 439080-01-0 |
| PubChem ID | 9894629 |
| InChI Key | XRJQDZXKLCOTGV-DOFZRALJSA-N |
| Smiles | O=C(N(CC2=CC(Cl)=C(O)C=C2)CC1=CC(Cl)=C(O)C=C1)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for O-2093
参考文献 for O-2093
参考文献是支持产品生物活性的出版物。
Di Marzo et al (2002) A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid. J.Pharmacol.Exp.Ther. 300 984 PMID: 11861807
Ligresti et al (2006) New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis. Br.J.Pharmacol. 147 83 PMID: 16284631
Griffin et al (2001) Activity of a novel anandamide analog suggests a non-CB1, non-VR1 site of action. 2001 Symposium on the Cannabinoids, International
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关键词: O-2093, O-2093 supplier, inhibitors, inhibits, anandamide, reuptake, AMT, Transporters, Cannabinoids, Monoamine, Neurotransmitter, Cannabinoid, 1446, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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