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Submit ReviewOBAA
说明： Phospholipase A2 inhibitor
化学名： 4-(4-Octadecylphenyl)-4-oxobutenoic acid
生物活性 for OBAA
OBAA is a potent inhibitor of phospholipase A2 (IC50 = 70 nM). Reduces bronchospasm in guinea pigs in vivo.
技术数据 for OBAA
| 分子量 | 428.65 |
| 公式 | C28H44O3 |
| 储存 | Desiccate at +4°C |
| CAS Number | 221632-26-4 |
| PubChem ID | 5353842 |
| InChI Key | ZBESASFHIWDSCJ-WCWDXBQESA-N |
| Smiles | CCCCCCCCCCCCCCCCCCC1=CC=C(C=C1)C(=O)\C=C\C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for OBAA
参考文献 for OBAA
参考文献是支持产品生物活性的出版物。
Kohler et al (1991) Phospholipase-A2 inhibition by alkylbenzoyl acrylic acids. Agents Actions 32 70 PMID: 2058477
Kohler et al (1992) Phospholipase A2 inhibition by alkylbenzoyl acrylic acids. Biochem.Pharmacol. 44 805 PMID: 1324685
Madi et al (1991) Allergen-induced bronchospasm in passively sensitized guinea-pigs - influence of new substances in comparison to reference compounds. Agents Actions 32 144 PMID: 2058463
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关键词: OBAA, OBAA supplier, Phospholipases, A2, inhibitors, inhibits, PLA, sPLA2, Esterases, 0606, Tocris Bioscience
2 篇 OBAA 的引用文献
引用文献是使用了 Tocris 产品的出版物。 OBAA 的部分引用包括：
Bianca et al (2010) Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2. Nat Commun 161 1835 PMID: 20825409
Kuo et al (2016) MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery. Am J Physiol Heart Circ Physiol 310 H71 PMID: 26519030
OBAA 的评论
平均评分: 5 (Based on 1 Review.)
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used this drug as an inhibitor.
By
Anonymous on 10/05/2017
分析类型： In Vitro
种属： Mouse
细胞系/组织： macrophages
Pretreat mouse macrophage cells with this inhibitor prior to the bacterial stimulation
