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说明： GABAA modulator; anxiolytic
化学名： 2-Pyridinyl[7-(4-pyridinyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone
纯度： ≥98% (HPLC)
生物活性 for Ocinaplon
Ocinaplon is a modulator of GABAA receptors. Displays modest selectivity for GABAA α1 receptors; displays partial agonist activity at α2-, α3- and α5-containing receptors. Exhibits anxiolytic activity.
技术数据 for Ocinaplon
| 分子量 | 301.3 |
| 公式 | C17H11N5O |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 96604-21-6 |
| PubChem ID | 216456 |
| InChI Key | OQJFBUOFGHPMSR-UHFFFAOYSA-N |
| Smiles | O=C(C4=CC=CC=N4)C2=C1N=CC=C(C3=CC=NC=C3)N1N=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Ocinaplon
参考文献 for Ocinaplon
参考文献是支持产品生物活性的出版物。
Mirza et al (2006) Comparative cue generalization profiles of L-838,417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, ZopiC., and various benzodiazepines in chlordiazep. and zol. drug discrimination. J.Pharmacol.Exp.Ther. 316 1291 PMID: 16339395
Lippa et al (2005) Selective anxiolysis produced by ocinaplon, a GABAA receptor modulator. Proc.Natl.Acad.Sci.USA 102 7380 PMID: 15870187
Rupprecht et al (2006) GABAA receptors as targets for novel anxiolytic drugs. World J.Biol.Psychiatry 7 231 PMID: 17071543
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关键词: Ocinaplon, Ocinaplon supplier, gabaa, α1, alpha1, a1, positive, modulators, anxiolytics, GABAA, Receptors, 4410, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.