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说明： Sleep-inducing brain lipid
化学名： cis-9-Octadecenamide
纯度： ≥98%
生物活性 for Oleamide
Oleamide is an endogenous sleep-inducing lipid. Acts as an agonist at the CB1 cannabinoid receptor (EC50 = 1.64 μM). Also appears to potentiate the actions of 5-HT on 5-HT2A and 2C receptors, and act via an allosteric regulatory site on 5-HT7 receptors.
技术数据 for Oleamide
| 分子量 | 281.48 |
| 公式 | C18H35NO |
| 储存 | Store at +4°C |
| 纯度 | ≥98% |
| CAS Number | 301-02-0 |
| PubChem ID | 5283387 |
| InChI Key | FATBGEAMYMYZAF-KTKRTIGZSA-N |
| Smiles | CCCCCCCC\C=C/CCCCCCCC(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Oleamide
参考文献 for Oleamide
参考文献是支持产品生物活性的出版物。
Cravatt et al (1995) Chemical characterisation of a family of brain lipids that induces sleep. Science 268 1506 PMID: 7770779
Hedlund et al (1999) Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors. Biochem.Pharmacol. 58 1807 PMID: 10571256
Huidobro-Toro and Harris (1996) Brain lipids that induce sleep are novel modulators of 5-hydroxytryptamine receptors. Proc.Natl.Acad.Sci.U.S.A. 93 8078 PMID: 8755606
Leggett et al (2004) Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors. Br.J.Pharmacol. 141 253 PMID: 14707029
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关键词: Oleamide, Oleamide supplier, Sleep-inducing, brain, lipid, Potentiator, 5-HT2A, 5-HT2C, receptors, CB1, agonists, Lipid, Metabolism, Serotonin, 5-Hydroxytryptamine, Cannabinoid, cb1r, 5-HT-Related, Receptors, Other, 0878, Tocris Bioscience
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