Oleylethanolamide

Cat. No. 1484 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Lipid mediator, anorexic actions; also GPR55 and PPARα agonist

化学名： (9Z)-N-(2-Hydroxyethyl)-9-octadecenamide

纯度： ≥99% (HPLC)

引用文献 (4)

生物活性技术数据说明书参考文献

生物活性 for Oleylethanolamide

Oleylethanolamide is a lipid mediator and analog of anandamide (Cat. No. 1339) that is involved in peripheral regulation of feeding. Selective GPR55 agonist (EC₅₀ values are 0.44, >30 and >30 μM at GPR55, CB₁ and CB₂ respectively) and PPARα agonist (EC₅₀ = 120 nM). Induces satiety through activation of PPARα and is also a ceramidase inhibitor. Also endogenous agonist at the GPR119 receptor.

技术数据 for Oleylethanolamide

分子量	325.53
公式	C₂₀H₃₉NO₂
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	111-58-0
PubChem ID	5283454
InChI Key	BOWVQLFMWHZBEF-KTKRTIGZSA-N
Smiles	CCCCCCCC\C=C/CCCCCCCC(=O)NCCO

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Oleylethanolamide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Oleylethanolamide

参考文献是支持产品生物活性的出版物。

Calignano et al (2001) Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide. Eur.J.Pharmacol. 419 191 PMID: 11426841

Coroneos et al (1995) Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. J.Biol.Chem. 270 23305 PMID: 7559485

de Fonseca et al (2001) An anorexic lipid mediator regulated by feeding. Nature 414 209 PMID: 11700558

Fu et al (2003) Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α. Nature 425 90 PMID: 12955147

Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092 PMID: 17876302

If you know of a relevant reference for Oleylethanolamide, please let us know.

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关键词: Oleylethanolamide, Oleylethanolamide supplier, Lipid, mediator, anorexic, actions, GPR55, PPARα, PPARalpha, agonists, Ceramidase, inhibitors, inhibits, Endogenous, GPR119, receptor, Peroxisome, Proliferator-activating, Receptors, PPAR, Cannabinoids, Ceramidases, Other, Metabolism, 1484, Tocris Bioscience