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Olvanil

Cat. No. 0934 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent TRPV agonist
别名： NE 19550
化学名： N-Vanillyloleoylamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Olvanil

Olvanil is a potent vanilloid receptor agonist (pEC50 values are 8.1 and 7.7 at rat and human VR1 receptors respectively). Also blocks anandamide uptake (IC50 = 9 μM) and may bind to CB1 cannabinoid receptors. Antinociceptive following systemic administration.

技术数据 for Olvanil

分子量 417.63
公式 C26H43NO3
储存 Desiccate at -20°C
纯度 ≥98% (HPLC)
CAS Number 58493-49-5
PubChem ID 5311093
InChI Key OPZKBPQVWDSATI-KHPPLWFESA-N
Smiles CCCCCCCC\C=C/CCCCCCCC(=O)NCC1=CC=C(O)C(OC)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Olvanil

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 100
ethanol 25

制备储备液 for Olvanil

以下数据基于产品分子量 417.63。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.39 mL 11.97 mL 23.94 mL
5 mM 0.48 mL 2.39 mL 4.79 mL
10 mM 0.24 mL 1.2 mL 2.39 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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产品说明书 for Olvanil

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Olvanil

参考文献是支持产品生物活性的出版物。

Di Marzo et al (1998) Interactions between synthetic vanilloids and the endogenous cannabinoid system. FEBS Lett. 436 449 PMID: 9801167

Dray et al (1990) NE-19550 and NE-21610, antinociceptive capsaicin analogues: studies on nociceptive fibres of the neonatal rat tail in vitro. Eur.J.Pharmacol. 181 289 PMID: 2384136

Janusz et al (1993) Vanilloids. 1. Analogs of capsaicin with antinociceptive and antiinflammatory activity. J.Med.Chem. 36 2595 PMID: 8410971

Ralevic et al (2001) Cannabinoid activation of recombinant and endogenous vanilloid receptors. Eur.J.Pharmacol. 424 211 PMID: 11672565

If you know of a relevant reference for Olvanil, please let us know.

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关键词: Olvanil, Olvanil supplier, Potent, vanilloid, agonists, Receptors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, NE19550, NE, 19550, 0934, Tocris Bioscience

1 篇 Olvanil 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Olvanil 的部分引用包括：

Witte et al (2002) Use of a fluorescent imaging plate reader--based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor. Am J Physiol Endocrinol Metab 7 466 PMID: 14599363

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