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Submit ReviewOMDM-2
说明： Potent inhibitor of anandamide uptake
化学名： (9Z)-N-[1-((R)-4-Hydroxbenzyl)-2-hydroxyethyl]-9-octadecenamide
纯度： ≥99% (HPLC)
生物活性 for OMDM-2
OMDM-2 is a metabolically stable inhibitor of anandamide cellular uptake (Ki = 3 μM). Displays relatively low affinity for CB1 and CB2 receptors (Ki values are 5.1 and > 10 μM) and for vanilloid VR1 receptors (EC50 = 10 μM). FABP inhibitor. Has minimal activity against FAAH (Ki > 50 μM). Active in vivo.
技术数据 for OMDM-2
| 分子量 | 431.66 |
| 公式 | C27H45NO3 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 616884-63-0 |
| PubChem ID | 9928181 |
| InChI Key | ITXVOUSORXSTQH-UHFFFAOYSA-N |
| Smiles | CCCCCCCC\C=C/CCCCCCCC(=O)N[C@@H](CO)CC1=CC=C(O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for OMDM-2
参考文献 for OMDM-2
参考文献是支持产品生物活性的出版物。
Ortar et al (2003) Novel selective and metabolically stable inhibitors of anandamide cellular uptake. Biochem.Pharmacol. 35 1473 PMID: 12732359
de Lago et al (2004) In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake. Eur.J.Pharmacol. 484 249 PMID: 14744610
Deutsch (2016) A personal retrospective: Elevating Anandamide (AEA) by targeting fatty acid amide hydrolase (FAAH) and the fatty acid binding proteins (FABPs). Front.Pharmacol. 7 370 PMID: 27790143
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关键词: OMDM-2, OMDM-2 supplier, Potent, inhibitors, inhibits, anandamide, reuptake, AMT, Transporters, cannabinoids, Monoamine, Neurotransmitter, FABPs, FABP, fatty, acid, binding, proteins, Cannabinoid, Fatty, Acid, Binding, Proteins, 1797, Tocris Bioscience
1 篇 OMDM-2 的引用文献
引用文献是使用了 Tocris 产品的出版物。 OMDM-2 的部分引用包括：
Bátkai et al (2004) Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. FASEB J 110 1996 PMID: 15451779
OMDM-2 的评论
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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