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Ononetin

Cat. No. 5143 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： TRPM3 blocker
化学名： 1-(2,4-Dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ononetin

Ononetin is a naturally occurring deoxybenzoin. TRPM3 channel blocker (IC50 = 300 nM). Inhibits pregnenolone sulfate-induced intracellular Ca2+ accumulation in HEKmTRPM3 cells and dorsal root ganglia (DRG) neurons in vitro.

技术数据 for Ononetin

分子量 258.27
公式 C15H14O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 487-49-0
PubChem ID 259632
InChI Key XHBZOAYMBBUURD-UHFFFAOYSA-N
Smiles COC1=CC=C(CC(C2=C(O)C=C(O)C=C2)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ononetin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 25.83 100
ethanol 25.83 100

制备储备液 for Ononetin

以下数据基于产品分子量 258.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.87 mL 19.36 mL 38.72 mL
5 mM 0.77 mL 3.87 mL 7.74 mL
10 mM 0.39 mL 1.94 mL 3.87 mL
50 mM 0.08 mL 0.39 mL 0.77 mL

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产品说明书 for Ononetin

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Ononetin

参考文献是支持产品生物活性的出版物。

Straub et al (2012) Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3. Br.J.Pharmacol. 168 1835 PMID: 23190005

If you know of a relevant reference for Ononetin, please let us know.

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关键词: Ononetin, Ononetin supplier, TRPM3, blockers, transient, receptor, potential, channels, TRPM, 5143, Tocris Bioscience

1 篇 Ononetin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Ononetin 的部分引用包括：

Son et al (2015) Hypotonic stress induces RANKL via transient receptor potential melastatin 3 (TRPM3) and vaniloid 4 (TRPV4) in human PDL cells. J Dent Res 94 473 PMID: 25595364

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