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Submit ReviewOrexin A (human, rat, mouse)
说明： Endogenous agonist at OX1 and OX2
纯度： ≥95% (HPLC)
生物活性 for Orexin A (human, rat, mouse)
Orexin A (human, rat, mouse) is an endogenous agonist with high affinity at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Orexin A stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions. Orexin A impairs neurogenesis and hippocampal plasticity in mice. Orexin A improves glucose control and beta cell functions in type 2 diabetic animals.
技术数据 for Orexin A (human, rat, mouse)
| 分子量 | 3561.12 |
| 公式 | C152H243N47O44S4 |
| 序列 |
XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL (Modifications: X = Glp, Disulfide bridges: 6-12, 7-14, Leu-33 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 205640-90-0 |
| PubChem ID | 90470982 |
| InChI Key | IXODJSWYPSZUCI-IIIOAANCSA-N |
| Smiles | [H]N1[C@@H](CCC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CNC=N2)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(N)=O)NC1=O)[C@@H](C)O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Orexin A (human, rat, mouse)
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for Orexin A (human, rat, mouse)
参考文献 for Orexin A (human, rat, mouse)
参考文献是支持产品生物活性的出版物。
Kilduff and Peyron (2000) The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. TiNS 23 359 PMID: 10906799
Sakurai et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92 573 PMID: 9491897
Smart (1999) Orexins: a new family of neuropeptides. Br.J.Anaesth. 83 695 PMID: 10690128
Forte et al (2021) Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice. Nat.Commun. 12 6137 PMID: 34675233
Kaczmarek et al (2017) Chronic orexin-A (hypocretin-1) treatment of type 2 diabetic rats improves glucose control and beta-cell functions. J.Physiol.Pharmacol. 68 669 PMID: 29375041
If you know of a relevant reference for Orexin A (human, rat, mouse), please let us know.
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关键词: Orexin A (human, rat, mouse), Orexin A (human, rat, mouse) supplier, Endogenous, agonists, OX1, OX2, Orexin, Non-Selective, Receptors, OrexinA, (human, rat, mouse), Non-selective, 1455, Tocris Bioscience
11 篇 Orexin A (human, rat, mouse) 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Orexin A (human, rat, mouse) 的部分引用包括：
Forte et al (2021) Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice. Nat.Commun. 12 6137 PMID: 34675233
Khoo et al (2017) The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking. PLoS One 12 PMID: 28296947
Lungwitz et al (2012) Orexin-A induces anxiety-like behavior through interactions with glutamatergic receptors in the bed nucleus of the stria terminalis of rats. Physiol Behav 107 726 PMID: 22652097
Burdyga et al (2010) Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype. Am J Physiol Gastrointest Liver Physiol 299 G63 PMID: 20430875
Kim et al (2015) Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells. Brain Res 19 327 PMID: 26170736
Shu et al (2014) Orexin-A promotes cell migration in cultured rat astrocytes via Ca2+-dependent PKCα and ERK1/2 signals. PLoS One 9 e95259 PMID: 24748172
Guo and Feng (2012) OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res 318 2004 PMID: 22652455
Moorman and Aston-Jones (2010) Orexin/hypocretin modulates response of ventral tegmental DA neurons to prefrontal activation: diurnal influences. J Neurosci 30 15585 PMID: 21084614
Kim and Han (2016) Functional Connectivity of Basolateral Amygdala Neurons Carrying Orexin Receptors and Melanin-concentrating Hormone Receptors in Regulating Sociability and Mood-related Behaviors. Exp Neurobiol 25 307 PMID: 28035181
Holland et al (2005) Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception. Korean J Physiol Pharmacol 315 1380 PMID: 16160082
Gompf and Aston-Jones (2008) Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity. J Pharmacol Exp Ther 1224 43 PMID: 18614159
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ICV injection in rats.
By
Chris Holton on 05/31/2020
分析类型： In Vivo
种属： Rat
ICV injection of orexin A at 20, 63 and 600 pmol in 2 uL aCSF in male Sprague Dawley rats under propofol anesthesia. Measurement of extracellular neuronal cell firing from the locus coeruleus. Clonidine 0.1 mg/kg i.p.
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