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Submit ReviewOrexin B (human)
说明： Endogenous agonist at OX1 and OX2
纯度： ≥95% (HPLC)
生物活性 for Orexin B (human)
Orexin B (human) is an endogenous agonist at orexin receptors (Ki values are 420 and 36 nM for OX1 and OX2 receptors, respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions. Also neuroprotective for dopaminergic neurons in rat midbrain cultures.
技术数据 for Orexin B (human)
| 分子量 | 2899.36 |
| 公式 | C123H212N44O35S |
| 序列 |
RSGPPGLQGRLQRLLQASGNHAAGILTM (Modifications: Met-28 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 205640-91-1 |
| PubChem ID | 90479794 |
| InChI Key | DHBREICAXZPFDD-WMQZXSDYSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Orexin B (human)
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for Orexin B (human)
参考文献 for Orexin B (human)
参考文献是支持产品生物活性的出版物。
Kilduff and Peyron (2000) The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. TiNS 23 359 PMID: 10906799
Sakurai et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92 573 PMID: 9491897
Smart (1999) Orexins: a new family of neuropeptides. Br.J.Anaesth. 83 695 PMID: 10690128
Guerreiro et al (2015) The sleep-modulating peptide orexin-B protects midbrain DA neurons from degeneration, alone or in cooperation with nicotine. Mol.Pharmacol. 87 525 PMID: 25552485
If you know of a relevant reference for Orexin B (human), please let us know.
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关键词: Orexin B (human), Orexin B (human) supplier, Endogenous, agonists, OX1, OX2, Orexin, Non-Selective, Receptors, OrexinB, (human), Non-selective, 1456, Tocris Bioscience
2 篇 Orexin B (human) 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Orexin B (human) 的部分引用包括：
Guerreiro et al (2015) The sleep-modulating peptide orexin-B protects midbrain DA neurons from degeneration, alone or in cooperation with nicotine. Mol.Pharmacol. 87 525 PMID: 25552485
Malherbe et al (2009) Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor. Br.J.Pharmacol. 156 1326 PMID: 19751316
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A neuropeptide with multiple functions.
By
Samanta Grella on 02/17/2022
分析类型： In Vivo
种属： Mouse
We used this drug to study its effect on brain proliferation. As shown in the attached image, we have found neural proliferation in the brain.
We always use freshly prepared drugs.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.