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Submit ReviewOrexin B (mouse)
说明： Endogenous agonist at OX1 and OX2
纯度： ≥95% (HPLC)
生物活性 for Orexin B (mouse)
Orexin B (mouse) is an endogenous agonist at orexin receptors. May be involved in the regulation of feeding, sleep-wake cycle and other hypothalamic functions. Orexin B exerts excitatory effects on nigral dopaminergic neurons and alleviates motor symptoms in a Parkinson's disease mouse model.
技术数据 for Orexin B (mouse)
| 分子量 | 2936.43 |
| 公式 | C126H215N45O34S |
| 序列 |
RPGPPGLQGRLQRLLQANGNHAAGILTM (Modification: Met-28 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 202801-92-1 |
| PubChem ID | 90479795 |
| InChI Key | RLVZFBVFVIDDPQ-GWQFQBPDSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Orexin B (mouse)
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for Orexin B (mouse)
参考文献 for Orexin B (mouse)
参考文献是支持产品生物活性的出版物。
Kilduff and Peyron (2000) The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. TiNS 23 359 PMID: 10906799
Sakurai et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92 573 PMID: 9491897
Smart (1999) Orexins: a new family of neuropeptides. Br.J.Anaesth. 83 695 PMID: 10690128
Bian et al (2021) Orexin-B exerts excitatory effects on nigral dopaminergic neurons and alleviates motor disorders in MPTP parkinsonian mice. Neurosci.Lett. 765 136291 PMID: 34666119
If you know of a relevant reference for Orexin B (mouse), please let us know.
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关键词: Orexin B (mouse), Orexin B (mouse) supplier, Endogenous, agonists, OX1, OX2, Orexin, Non-Selective, Receptors, OrexinB, (mouse), hypocretin, Non-selective, 1457, Tocris Bioscience
3 篇 Orexin B (mouse) 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Orexin B (mouse) 的部分引用包括：
Guo and Feng (2012) OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res 318 2004 PMID: 22652455
Bian et al (2021) Orexin-B exerts excitatory effects on nigral dopaminergic neurons and alleviates motor disorders in MPTP parkinsonian mice Neurosci Lett 765 136291 PMID: 34666119
Holland et al (2005) Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception. J Biol Chem 315 1380 PMID: 16160082
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Orexin B (mouse) 的评论
平均评分: 5 (Based on 1 Review.)
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High quality peptide.
By
Samanta Grella on 11/18/2022
分析类型： In Vitro
种属： Mouse
This is the second Tocris peptide we have used in our study. The first one was from human origin (product #1456). Because a colleague suggested us to repeat the experiment with a peptide from mouse origin; we have chosen this product (Orexin B mouse). The results were amazing because the neuronal activation has increased at a level we were expecting to conduct the behavioural analysis. As shown in the attached graph, this compound stimulated neuronal activity at a hippocampus nuclei, as measured by immunoflurescence after compound delivery into the brain. We are very satisfied with the result and I recommed this Tocris product.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.