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Org 24598

Cat. No. 4447 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective inhibitor of the glial glycine transporter GlyT1b; active in vivo
化学名： N-Methyl-N-[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]-glycine
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Org 24598

Org 24598 is a potent and selective inhibitor of the glial glycine transporter GlyT1b (IC50 = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transporters (pIC50 < 4). Active in vivo.

技术数据 for Org 24598

分子量 367.36
公式 C19H20F3NO3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 372198-97-5
PubChem ID 5311285
InChI Key KZWQAWBTWNPFPW-QGZVFWFLSA-N
Smiles CN(CC(O)=O)CC[C@@H](OC2=CC=C(C(F)(F)F)C=C2)C1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Org 24598

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.74 100

制备储备液 for Org 24598

以下数据基于产品分子量 367.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.72 mL 13.61 mL 27.22 mL
5 mM 0.54 mL 2.72 mL 5.44 mL
10 mM 0.27 mL 1.36 mL 2.72 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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产品说明书 for Org 24598

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Org 24598

参考文献是支持产品生物活性的出版物。

Chue et al (2013) Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1). Curr.Pharm.Des. 19 1311 PMID: 23194655

Brown et al (2001) Discovery and SAR of org 24598-a selective glycine uptake inhibitor. Bioorg.Med.Chem.Lett. 11 2007 PMID: 11454468

Williams et al (2003) Development of a scintillation proximity assay for analysis of Na+/Cl- -dependent neurotransmitter transporter activity. Anal. Biochem. 321 31 PMID: 12963052

If you know of a relevant reference for Org 24598, please let us know.

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关键词: Org 24598, Org 24598 supplier, Org24598, glial, glycine, transporters, glyt1, inhibitors, inhibits, Glycine, Transporters, 4447, Tocris Bioscience

1 篇 Org 24598 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Org 24598 的部分引用包括：

Jaekwang et al (2020) The molecular mechanism of synaptic activity-induced astrocytic volume transient. J Physiol 598 4555-4572 PMID: 32706443

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