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Org 48762-0

Cat. No. 6014 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6014 has been discontinued.

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说明： Selective p38α/β inhibitor; orally bioavailable
化学名： 4,6-Bis(4-fluorophenyl)-2-methyl-5-(4-pyridinyl)-2H-pyrazolo[3,4-b]pyridine
纯度： ≥98% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for Org 48762-0

Org 48762-0 is a selective p38α and β kinase inhibitor (EC50 = 0.1 μM for p38α). Selective for p38α/β over a panel of 48 other human kinases. Inhibits LPS-induced TNFα release from PBMCs. Also inhibits cytokine release in an LPS-induced endotoxemia model in mice. Orally bioavailable.

技术数据 for Org 48762-0

分子量 398.41
公式 C24H16F2N4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 755753-89-0
PubChem ID 24822135
InChI Key VMAKTIDYMSNPOV-UHFFFAOYSA-N
Smiles CN1C=C2C(N=C(C(C3=CC=NC=C3)=C2C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Org 48762-0

参考文献是支持产品生物活性的出版物。

Mihara et al (2008) A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFalpha. Br.J.Pharmacol. 154 153 PMID: 18297096

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关键词: Org 48762-0, Org 48762-0 supplier, Org48762-0, MAPK, mitogen-activated, protein, kinases, inhibitors, inhibits, p38, α, β, alpha, beta, selective, orally, bioavailable, 6014, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for Org 48762-0

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.