主页 / 药理学 / GPCRs / 7-TM Receptors / Orphan 7-TM Receptors / Orphan 7-TM Receptor Agonists / OX 04528

OX 04528

Cat. No. 8131 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Highly potent and selective GPR84 agonist
化学名： 3-(3-(3,5-Bis(trifluoromethyl)phenyl)propyl)-5-hydroxypyridine-1-oxide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for OX 04528

OX 04528 is a highly potent and selective GPR84 agonist. It inhibits cAMP production in CHO cells expressing human GPR84 (EC50 = 6 pM) and shows no β-arrestin recruitment. Exhibits selectivity for GPR84 over FFA1, FFA4, and CB2 receptors. In vivo, OX 04528 shows a half-life of 58 minutes following oral dosing at 10 mg/kg in mouse pharmacokinetic studies. OX 04528 is orally bioavailable.

技术数据 for OX 04528

分子量 365.28
公式 C16H13F6NO2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 3028055-45-7
PubChem ID 170453166
InChI Key DPLHUGXFERHOJE-UHFFFAOYSA-N
Smiles [O-][N+]1=CC(CCCC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=CC(O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for OX 04528

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.53 100
ethanol 36.53 100

制备储备液 for OX 04528

以下数据基于产品分子量 365.28。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.69 mL 27.38 mL
5 mM 0.55 mL 2.74 mL 5.48 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for OX 04528

参考文献是支持产品生物活性的出版物。

Wang et al (2024) Development of highly potent, G-protein pathway biased, selective, and orally bioavailable GPR84 agonists. J.Med.Chem. 67 110 PMID: 38146625

If you know of a relevant reference for OX 04528, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Orphan 7-TM Receptor Agonists

关键词: OX 04528, OX 04528 supplier, OX04528, potent, selective, GPR84, agonists, agonism, in, vivo, orally, bioavailable, Orphan, 7-TM, Receptors, 8131, Tocris Bioscience

篇 OX 04528 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 OX 04528 的引用文献。 您是否知道使用了 Tocris OX 04528 的优秀论文？ 请告知我们.

OX 04528 的评论

目前没有该产品的评论。 Be the first to review OX 04528 and earn rewards!

Have you used OX 04528?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review