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Submit ReviewOxotremorine M
说明： Muscarinic agonist
化学名： N,N,N-Trimethyl-4-(2-oxo-1-pyrolidinyl)-2-butyn-1-ammonium iodide
纯度： ≥98% (HPLC)
生物活性 for Oxotremorine M
Oxotremorine M is a muscarinic receptor agonist. Also directly potentiates NMDA-mediated ion currents.
技术数据 for Oxotremorine M
| 分子量 | 322.19 |
| 公式 | C11H19IN2O |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 3854-04-4 |
| PubChem ID | 3027782 |
| InChI Key | VVLMSCJCXMBGDI-UHFFFAOYSA-M |
| Smiles | O=C1N(CC#CC[N+](C)(C)C)CCC1.[I-] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Oxotremorine M
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 32.22 | 100 |
制备储备液 for Oxotremorine M
以下数据基于产品分子量 322.19。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.1 mL | 15.52 mL | 31.04 mL |
| 5 mM | 0.62 mL | 3.1 mL | 6.21 mL |
| 10 mM | 0.31 mL | 1.55 mL | 3.1 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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产品说明书 for Oxotremorine M
参考文献 for Oxotremorine M
参考文献是支持产品生物活性的出版物。
Birdsall et al (1978) The binding of agonists to brain muscarinic receptors. Mol.Pharmacol. 14 723 PMID: 714021
Kukkonen et al (1996) Functional properties of muscarinic receptor subtypes Hm1, Hm3 and Hm5 expressed in Sf9 cells using the baculovirus expression system. J.Pharmacol.Exp.Ther. 279 593 PMID: 8930161
Zwart et al (2017) Oxotremorine-M potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms. Biochem.Biophys.Res.Commun. 495 481 PMID: 29127015
If you know of a relevant reference for Oxotremorine M, please let us know.
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关键词: Oxotremorine M, Oxotremorine M supplier, Muscarinic, agonists, Receptors, Acetylcholine, ACh, OxotremorineM, NMDA, potentiator, potentiates, Non-selective, Muscarinics, 1067, Tocris Bioscience
14 篇 Oxotremorine M 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Oxotremorine M 的部分引用包括：
Ahsan Raza (2017) HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience. Nat Commun 8 189 PMID: 28775269
Roberts-Crowley and Rittenhouse (2015) Characterization of ST14A Cells for Studying Modulation of Voltage-Gated Calcium Channels. Front Behav Neurosci 10 e0132469 PMID: 26147123
Won et al (2011) Identification and modulation of voltage-gated Ca2+ currents in zebrafish Rohon-Beard neurons. J Neurophysiol 105 442 PMID: 20962070
Abiraman et al (2015) Anti-muscarinic adjunct therapy accelerates functional human oligodendrocyte repair. PLoS One 35 3676 PMID: 25716865
Parent et al (2015) Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability. Proc Natl Acad Sci U S A 9 284 PMID: 26578914
Shin et al (2015) Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens. J Neurosci 112 8124 PMID: 26080439
Won et al (2012) Characterization of Na+ and Ca2+ channels in zebrafish dorsal root ganglion neurons. PLoS One 7 e42602 PMID: 22880050
Deng et al (2013) Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors. J Pharmacol Toxicol Methods 68 323 PMID: 23933114
Saxena et al (2013) Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival. Neuron 80 80 PMID: 24094105
Buchanan et al (2010) Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels. Neuron 68 948 PMID: 21145007
Wilke et al (2014) Diacylglycerol mediates regulation of TASK potassium channels by Gq-coupled receptors. Nat Commun 5 5540 PMID: 25420509
Daigle and Caron (2012) Elimination of GRK2 from cholinergic neurons reduces behavioral sensitivity to muscarinic receptor activation. J Neurosci 32 11461 PMID: 22895728
Filippov et al (2010) The scaffold protein NHERF2 determines the coupling of P2Y1 nucleotide and mGluR5 glutamate receptor to different ion channels in neurons. PLoS One 30 11068 PMID: 20720114
Narushima et al (2007) Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum. J Neurosci 27 496 PMID: 17234582
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