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说明： Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable
纯度： ≥95% (HPLC)
生物活性 for P110
P110 is a dynamin-related protein 1 (Drp1) inhibitor, inhibits Drp1 GTPase activity. Displays no effect on dynamin 1 or other mitochondrial dynamics-related proteins. Inhibits mitochondrial fission, dysfunction and reactive oxygen species (ROS) production in vitro. Reduces programmed cell death and improves cell viability by protecting mitochondrial integrity. Reduces mitochondrial fragmentation and mitochondrial ROS production in mouse model of Parkinson's disease. Cell permeable.
技术数据 for P110
| 分子量 | 2411.8 |
| 公式 | C100H179N45O25 |
| 序列 |
YGRKKRRQRRRGGDLLPRGS (Modification: Ser-20 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 2770267-63-3 |
| InChI Key | TYQHBBMTJWPEDH-VZOPDNRXSA-N |
| Smiles | [H]N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCC(N[C@H](C(N)=O)CO)=O)=O)CCCNC(N)=N)=O)=O)CC(C)C)=O)CC(C)C)=O)CC(O)=O)=O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)CCCNC(N)=N)=O)=O)CC2=CC=C(C=C2)O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for P110
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for P110
参考文献 for P110
参考文献是支持产品生物活性的出版物。
Qi et al (2013) A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J.Cell Sci. 126 789 PMID: 23239023
Filichia et al (2016) Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson's disease model induced by MPTP. Sci.Rep. 13 32656 PMID: 27619562
If you know of a relevant reference for P110, please let us know.
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关键词: P110, P110 supplier, dynamin, related, protein, 1, inhibitors, inhibits, mitochondrial, fission, dysfunction, mitochondria, Dynamin, 6897, Tocris Bioscience
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