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说明： Protein disulfide isomerase (PDI) inhibitor
化学名： N-[(1,1-Dimethylethoxy)carbonyl]-L-phenylalanyl-O-(ethenylsulfonyl)-N-4-pentyn-1-yl-L-tyrosinamide
纯度： ≥98% (HPLC)
生物活性 for P1
P1 is a protein disulfide isomerase (PDI) inhibitor (IC50 = 1.7 μM). Inhibits proliferation of numerous cancer cell lines. Cell permeable.
技术数据 for P1
| 分子量 | 583.7 |
| 公式 | C30H37N3O7S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1461648-55-4 |
| PubChem ID | 91826082 |
| InChI Key | RNMDSOKRNOMQFX-UIOOFZCWSA-N |
| Smiles | O=[C@@](NCCCC#C)[C@@H](NC([C@@H](NC(OC(C)(C)C)=O)CC2=CC=CC=C2)=O)CC1=CC=C(OS(C=C)(=O)=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for P1
参考文献 for P1
参考文献是支持产品生物活性的出版物。
Ge et al (2013) Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase ACS Chem.Biol. 8 2577 PMID: 24070012
Xu et al (2013) Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization. PLoS One 8 e76657 PMID: 24098548
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关键词: P1, P1 supplier, Protein, disulfide, Isomerase, PDI, inhibitors, inhibits, Disulfide, 5127, Tocris Bioscience
1 篇 P1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 P1 的部分引用包括：
Chia-Yi et al (2022) Hyperglycemia exacerbates dengue virus infection by facilitating poly(A)-binding protein-mediated viral translation. JCI Insight 7 PMID: 36125898
P1 的评论
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Gut Hormones Poster
The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect digestion, appetite and energy expenditure. Neuropeptide modulators and gut hormones that influence appetite are reviewed in this poster.