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Submit ReviewPA 452
说明： RXR antagonist
化学名： 2-[[3-(Hexyloxy)-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methylamino]-5-pyrimidinecarboxylic acid
纯度： ≥98% (HPLC)
生物活性 for PA 452
PA 452 is an RXR antagonist (pA2 = 7.11). Triggers dissociation of RXR tetramers. Attenuates cell proliferation and induces apoptosis in MCF-7 breast cancer cells.
技术数据 for PA 452
| 分子量 | 439.59 |
| 公式 | C26H37N3O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 457657-34-0 |
| PubChem ID | 9803242 |
| InChI Key | JJUUTJCZMGZJDZ-UHFFFAOYSA-N |
| Smiles | CC1(C)C2=C(C=C(N(C3=NC=C(C(O)=O)C=N3)C)C(OCCCCCC)=C2)C(C)(C)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PA 452
参考文献 for PA 452
参考文献是支持产品生物活性的出版物。
Yasmin et al (2010) Inhibition of mammary carcinoma cell growth by RXR is mediated by the receptor's oligomeric switch. J.Mol.Biol. 397 1121 PMID: 20188110
Takahashi et al (2002) Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions. J.Med.Chem. 45 3327 PMID: 12139443
Nakayama et al (2011) Discovery of a potent retinoid X receptor antagonist structurally closely related to RXR agonist NEt-3IBIB. J.Med.Chem.Lett 2 896 PMID: 24900278
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关键词: PA 452, PA 452 supplier, PA452, RXR, tetramers, retinoid, X, receptors, antagonists, Retinoid, Receptor, 5086, Tocris Bioscience
2 篇 PA 452 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PA 452 的部分引用包括：
Yuan et al (2018) A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cell for the Chronic Hepatitis B Virus Infection. Front Microbiol 9 908 PMID: 29867819
Wang et al (2017) Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylation. J Mol Cell Biol 9 338 PMID: 28992291
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.