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Pam2CSK4

Cat. No. 4637 3 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： TLR2/6 agonist; induces TNF-α production
纯度： ≥95% (HPLC)
说明书
引用文献 (3)
评论 (1)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Pam2CSK4

Pam2CSK4 is a toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.

技术数据 for Pam2CSK4

分子量 1271.83
公式 C65H126N10O12S
序列 CSKKKK

(Modifications: Cys-1 = S-[2,3-Bis(palmitoyloxy)-(2-R)-propyl]-Cys)
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 868247-72-7
PubChem ID 71457280
InChI Key LJUIOEFZFQRWJG-GHYFRYPYSA-N
Smiles [H]N[C@@H](CSC[C@@H](COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Pam2CSK4

溶解性 Soluble to 1 mg/ml in 0.25% acetic acid

产品说明书 for Pam2CSK4

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参考文献 for Pam2CSK4

参考文献是支持产品生物活性的出版物。

Boeglin et al (2011) Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells. PLoS One 6 e25542 PMID: 21991317

Omueti et al (2005) Domain exchange between human Toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination. J.Biol.Chem. 280 36616 PMID: 16129684

Schromm et al (2007) Physiochemical and biological analysis of synthetic bacterial lipopeptides: validity of the concept of endotoxic conformation. J.Biol.Chem. 282 11030 PMID: 17308304

If you know of a relevant reference for Pam2CSK4, please let us know.

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关键词: Pam2CSK4, Pam2CSK4 supplier, TLR2, TLR6, agonists, Toll-like, receptors, induces, inducers, TNF-a, TNF-alpha, TNF-α, tumor, tumour, necrosis, factor, production, Receptors, 4637, Tocris Bioscience

3 篇 Pam2CSK4 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Pam2CSK4 的部分引用包括：

Alexa et al (2023) Anti-inflammatory properties of antiangiogenic fucoidan in retinal pigment epithelium cells. Heliyon 9 e15202 PMID: 37123974

Hari et al (2019) The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype. Sci Adv 5 eaaw0254 PMID: 31183403

Valerie G et al (2022) Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence. Cell Death Differ 29 1267-1282 PMID: 34916628

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Pam2CSK4 的评论

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Pam2CSK4 induces TNFa production and release.
By Anonymous on 12/12/2018
分析类型： In Vitro
种属： Mouse
细胞系/组织： Macrophages

Raw macrophages were stimulated either with LPS (200 ng/ml) or Pam2CSK4 (50 nM) for 8 h to follow TNFa concentration in cell culture medium using ELISA. Pam2CSK4 induced TNFa production and release in a similar extent as LPS.

review image

Pathways for Pam2CSK4

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.