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Submit ReviewPam3CSK4
说明： TLR1/2 agonist; induces cytokine production
纯度： ≥95% (HPLC)
生物活性 for Pam3CSK4
Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist; induces production of TNF-α and IL-6 in macrophages. Stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells. Promotes differentiation of naive CD4+ T cells into Th17 cells.
技术数据 for Pam3CSK4
| 分子量 | 1510.24 |
| 公式 | C81H156N10O13S |
| 序列 |
CSKKKK (Modifications: Cys-1 = S-[2,3-Bis(palmitoyloxy)-(2-R/S)-propyl]-N-palmitoyl]-Cys |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 112208-00-1 |
| PubChem ID | 130704 |
| InChI Key | OEDPHAKKZGDBEV-GFPBKZJXSA-N |
| Smiles | [H]N([C@@H](CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O)C(=O)CCCCCCCCCCCCCCC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Pam3CSK4
| 溶解性 | Soluble to 1 mg/ml in 50% Ethanol / water |
产品说明书 for Pam3CSK4
参考文献 for Pam3CSK4
参考文献是支持产品生物活性的出版物。
St Paul et al (2012) Toll-like receptor ligands induce the expression of IF.-gamma and interleukin-17 in chicken CD4+ T cells. BMC Res.Notes 1 616 PMID: 23116495
Offermanns et al (1992) Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells. Biochem.J. 282 551 PMID: 1312332
Caproni et al (2012) MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action. J.Immunol. 188 3088 PMID: 22351935
If you know of a relevant reference for Pam3CSK4, please let us know.
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关键词: Pam3CSK4, Pam3CSK4 supplier, toll, like, receptors, TLRs, agonists, ligands, induces, cytokines, production, IFNg, TNFa, TNFalpha, IL-6, interleukin, Toll-like, Receptors, 4633, Tocris Bioscience
3 篇 Pam3CSK4 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Pam3CSK4 的部分引用包括：
Valerie G et al (2022) Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence. Cell Death Differ 29 1267-1282 PMID: 34916628
Tomio et al (2020) Dietary Fiber Pectin Ameliorates Experimental Colitis in a Neutral Sugar Side Chain-Dependent Manner. Front Immunol 10 2979 PMID: 31921214
Alicja et al (2020) Integrative analysis suggests cell type-specific decoding of NF-κB dynamics. Sci Signal 13 PMID: 32098801
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Pam3CSK4 的评论
平均评分: 5 (基于 2 条评论。)
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Pam3CSK4 inducer works great.
By
Xiaogang Wang on 06/21/2021
分析类型： In Vitro
种属： Human
细胞系/组织： differentiated human macrophages
We used 50 ng/ml of Pam3CSK4 to treat differentiated human macrophages for 2 h at 37C and measured the IL-6 production in culture supernatants of macrophages. As shown in the attached image, Pam3CSK4 treatment, but not untreated cells, significantly induced IL-6 production in human macrophages.
TLR 1/2 agonist.
By
Tahmineh Safaie on 01/22/2020
分析类型： In Vitro
种属： Mouse
细胞系/组织： Raw-Blue
Raw-Blue Cell lines were treated with 125 ng/ml of PAM3CSK4 and the level of SEAP was measured. SEAP level correlates with NFkB activation
Pathways for Pam3CSK4
