Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPanobinostat
说明： Pan-histone deacetylase inhibitor
化学名： (2E)-N-Hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide
纯度： ≥98% (HPLC)
生物活性 for Panobinostat
Panobinostat is a potent pan-histone deacetylase (HDAC) inhibitor (IC50 values = 2.1 - 531 nM). Panobinostat induces histone H3 and H4 acetylation and potently inhibits cell proliferation and cell viability in HH, BT474 and HCT116 cells (IC50 are 1.8, 2.6 and 7.1 nM, respectively) in vitro. It leads to significant tumor regression of up to 94% in an HH CTCL mouse xenograft model. Panobinostat inhibits the DNA binding activity of STAT5 in leukemia cell lines and acts synergistically with 17-AAG (Cat. No. 1515) to induce apoptosis. The compound shows potent antimyeloma activity, including in drug-resistant cell lines. Panobinostat also induces a significant increase in cell-associated unspliced (CA-US) HIV-1 RNA from CD4+ T cells and leads to activation of transcription of proviruses. Panobinostat simultaneously suppresses the expression of angiotensin-converting enzyme 2 (ACE2) and ABO in epithelial cell lines. Antimalarial and orally bioavailable.
技术数据 for Panobinostat
| 分子量 | 349.43 |
| 公式 | C21H23N3O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 404950-80-7 |
| PubChem ID | 6918837 |
| InChI Key | FPOHNWQLNRZRFC-ZHACJKMWSA-N |
| Smiles | ONC(/C=C/C(C=C1)=CC=C1CNCCC2=C(C)NC3=CC=CC=C23)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Panobinostat
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 34.94 | 100 |
制备储备液 for Panobinostat
以下数据基于产品分子量 349.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.86 mL | 14.31 mL | 28.62 mL |
| 5 mM | 0.57 mL | 2.86 mL | 5.72 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.86 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for Panobinostat
参考文献 for Panobinostat
参考文献是支持产品生物活性的出版物。
Atadja (2009) Development of the pan-DAC inhibitor panobinostat (LBH589): successes and challenges. Cancer Lett. 280 233 PMID: 19344997
Maiso et al (2006) The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance. Cancer Res. 66 5781 PMID: 16740717
George et al (2005) Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3. Blood 105 1768 PMID: 15514006
Barton et al (2016) Broad activation of latent HIV-1 in vivo. Nat.Commun. 7 12731 PMID: 27605062
Takahashi et al (2021) Histone deacetylase inhibitors suppress ACE2 and ABO simultaneously, suggesting a preventive potential against COVID-19. Sci.Rep. 11 3379 PMID: 33564039
If you know of a relevant reference for Panobinostat, please let us know.
关键词: Panobinostat, Panobinostat supplier, pan, histone, deacetylase, HDAC, inhibitor, inhibits, tumor, regression, H3, H4, acetylation, antimyeloma, cell-associated, unspliced, CA-US, HIV-1, RNA, angiotensin-converting, enzyme, 2, ACE2, ABO, COVID-19, antimalarial, malaria, Non-selective, HDACs, Antimalarials, 7629, Tocris Bioscience
篇 Panobinostat 的引用文献
引用文献是使用了 Tocris 产品的出版物。
目前没有 Panobinostat 的引用文献。 您是否知道使用了 Tocris Panobinostat 的优秀论文？ 请告知我们.
Panobinostat 的评论
目前没有该产品的评论。 Be the first to review Panobinostat and earn rewards!
Have you used Panobinostat?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.