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Submit ReviewPD 173212
说明： Potent CaV2.2 blocker
化学名： N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide
纯度： ≥98% (HPLC)
生物活性 for PD 173212
PD 173212 is a potent N-type voltage-gated calcium channel blocker (IC50 = 36 nM). Displays selectivity over K+, Na+ and L-type Ca2+ channels. Prevents tonic seizures in the audiogenic seizure model in vivo.
技术数据 for PD 173212
| 分子量 | 599.85 |
| 公式 | C38H53N3O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 217171-01-2 |
| PubChem ID | 9916734 |
| InChI Key | GCDHMGROXQUFNR-HEVIKAOCSA-N |
| Smiles | CC(C)(C)C1=CC=C(CN(C)[C@H](C(N[C@H]([C@](NC(C)(C)C)=O)CC2=CC=C(OCC3=CC=CC=C3)C=C2)=O)CC(C)C)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PD 173212
参考文献 for PD 173212
参考文献是支持产品生物活性的出版物。
Hu et al (1999) Structure-activity relationships of N-methyl-N-aralkyl-peptidylamines as novel N-type calcium channel blockers. Bioorg.Med.Chem.Letts. 9 2151
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关键词: PD 173212, PD 173212 supplier, Potent, N-type, Ca2+, channel, blockers, Calcium, CaV, Channels, voltage-gated, voltage-dependent, PD173212, Cav2.x, 3552, Tocris Bioscience
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