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Submit ReviewPD 404182
说明： High affinity inhibitor of KDO 8-P synthase; also DDAH1 inhibitor
化学名： 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
纯度： ≥98% (HPLC)
生物活性 for PD 404182
High affinity inhibitor of KDO 8-P synthase (Ki = 26 nM). Also inhibits dimethylarginine dimethylaminohydrolase 1 (DDAH1). Exhibits antiangiogenic and antiviral activity in vitro. Putative antibiotic against gram-negative bacteria.
技术数据 for PD 404182
| 分子量 | 217.29 |
| 公式 | C11H11N3S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 72596-74-8 |
| PubChem ID | 6603967 |
| InChI Key | JNENSSREQFBZGT-UHFFFAOYSA-N |
| Smiles | N=C2SC1=CC=CC=C1C3=NCCCN23 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PD 404182
参考文献 for PD 404182
参考文献是支持产品生物活性的出版物。
Birck et al (2000) Identification of a slow tight-binding inhibitor of 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase. J.Am.Chem.Soc. 122 9334
Ghebremariam et al (2013) A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide. J.Pharmacol.Exp.Ther. 348 69 PMID: 24135074
Chamoun-Emanuelli et al (2014) Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide. Antimicrob.Agents Chemother. 58 687 PMID: 24217696
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关键词: PD 404182, PD 404182 supplier, PD404182, antibiotics, KDO8-P, antivirals, antiangiogenics, angiogenesis, gram, negative, DDAH1, 3-deoxy-D-manno-octulosonic, acid, 8-phosphate, synthase, dimethylarginine, dimethylaminohydrolase, 1, inhibits, inhibitors, Other, Synthases/Synthetases, Hydrolases, 5124, Tocris Bioscience
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