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说明： Potent PARG inhibitor
化学名： 1-[(2,4-Dimethyl-5-thiazolyl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide
纯度： ≥98% (HPLC)
生物活性 for PDD 00017272
PDD 00017272 is a potent poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 values are 4.8 nM in biochemical assay and 9.2 nM in cell based assay).
许可信息
Sold under license from Cancer Research Technology Ltd (Ximbio).
技术数据 for PDD 00017272
| 分子量 | 531.66 |
| 公式 | C23H25N5O4S3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1945950-20-8 |
| PubChem ID | 134169694 |
| InChI Key | QOEXRJYTAZZRPL-UHFFFAOYSA-N |
| Smiles | CC1=NC=C(S1)CN2C(N(C3=CC=C(S(=O)(NC4(CC4)C)=O)C=C3C2=O)CC5=C(N=C(S5)C)C)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PDD 00017272
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 10.63 | 20 温和加热 |
制备储备液 for PDD 00017272
以下数据基于产品分子量 531.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 9.4 mL | 47.02 mL | 94.05 mL |
| 1 mM | 1.88 mL | 9.4 mL | 18.81 mL |
| 2 mM | 0.94 mL | 4.7 mL | 9.4 mL |
| 10 mM | 0.19 mL | 0.94 mL | 1.88 mL |
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产品说明书 for PDD 00017272
参考文献 for PDD 00017272
参考文献是支持产品生物活性的出版物。
Waszkowycz et al (2018) Cell-active small molecule inhibitors of the DNA-damage repair enzyme poly(ADP-ribose) glycohydrolase (PARG): discovery and optimization of orally bioavailable quinazolinedione sulfonamides. J.Med.Chem. 61 10767 PMID: 30403352
If you know of a relevant reference for PDD 00017272, please let us know.
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关键词: PDD 00017272, PDD 00017272 supplier, PDD00017272, PARG, inhibitors, poly, ADP, ribose, glycohydrolase, inhibits, PDDX-004, potent, Poly(ADP)-ribose, Glycohydrolase, 7006, Tocris Bioscience
1 篇 PDD 00017272 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PDD 00017272 的部分引用包括：
Petropoulos et al (2024) Transcription-replication conflicts underlie sensitivity to PARP inhibitors. Nature 628 433 PMID: 38509368
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