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Submit ReviewPDZ1 Domain inhibitor peptide
说明： Disrupts interaction between GluK2 and PSD-95 PDZ1 domain
生物活性 for PDZ1 Domain inhibitor peptide
PDZ1 Domain inhibitor peptide is a novel cyclic peptide that disrupts interaction between GluK2 (formerlyy GluR6) and the postsynaptic density protein 95 (PSD-95). Competes with the C-terminus of GluK2 for binding to the PDZ1 domain of PSD-95. Inhibits clustering of kainate receptors.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
技术数据 for PDZ1 Domain inhibitor peptide
| 分子量 | 819.95 |
| 公式 | C38H61N9O11 |
| 序列 |
YKKTEAV (Modifications: Ala-6 = β-Ala, Cyclized = Lys-3 - Ala-6)) |
| 储存 | Desiccate at -20°C |
| CAS Number | 1315378-73-4 |
| PubChem ID | 90488746 |
| InChI Key | XXRRADBJCXMGOW-RMLJCASOSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PDZ1 Domain inhibitor peptide
参考文献 for PDZ1 Domain inhibitor peptide
参考文献是支持产品生物活性的出版物。
Piserchio et al (2004) Targeting specific PDZ domains of PSD-95: structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. Chem.Biol. 11 469 PMID: 15123241
关键词: PDZ1 Domain inhibitor peptide, PDZ1 Domain inhibitor peptide supplier, Disrupts, interaction, between, GluR6, PSD-95, PDZ1, domain, Glutamate, Kainate, Receptors, iGluR, Ionotropic, GluK2, 2207, Tocris Bioscience
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