主页 / 药理学 / Ion Channels / Ligand-gated Ion Channels / GABAA and GABAA-ρ Receptors / Miscellaneous GABA / Pentylenetetrazole

Pentylenetetrazole

Cat. No. 2687 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： CNS stimulant
别名： PTZ
化学名： 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论 (1)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Pentylenetetrazole

Pentylenetetrazole is a cNS stimulant that induces kindling in vivo. Causes alterations in excitatory and inhibitory neurotransmitter systems.

技术数据 for Pentylenetetrazole

分子量 138.17
公式 C6H10N4
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 54-95-5
PubChem ID 5917
InChI Key CWRVKFFCRWGWCS-UHFFFAOYSA-N
Smiles C1CCN2N=NN=C2CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Pentylenetetrazole

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 13.81 100
DMSO 13.81 100

制备储备液 for Pentylenetetrazole

以下数据基于产品分子量 138.17。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 7.24 mL 36.19 mL 72.37 mL
5 mM 1.45 mL 7.24 mL 14.47 mL
10 mM 0.72 mL 3.62 mL 7.24 mL
50 mM 0.14 mL 0.72 mL 1.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for Pentylenetetrazole

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Pentylenetetrazole

参考文献是支持产品生物活性的出版物。

Rocha et al (1996) Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems. Epilepsy Res. 26 105 PMID: 8985692

Walsh et al (1999) Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density. J.Pharmacol.Exp.Ther. 289 1626 PMID: 10336561

Dhir et al (2006) Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action. Prog.Neuro-Psychopharm.Biol.Psychiat. 30 1478

If you know of a relevant reference for Pentylenetetrazole, please let us know.

按标靶查看相关产品

关键词: Pentylenetetrazole, Pentylenetetrazole supplier, CNS, stimulant, Glutamate, mGlur, Receptors, Metabotropic, iGluR, Ionotropic, GABAB, GABAA, GABAC, PTZ, Miscellaneous, GABA, 2687, Tocris Bioscience

1 篇 Pentylenetetrazole 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Pentylenetetrazole 的部分引用包括：

Karim et al (2012) 2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. Br J Pharmacol 165 880 PMID: 21797842

您是否知道使用了 Tocris Pentylenetetrazole 的优秀论文？ 请告知我们.

Pentylenetetrazole 的评论

平均评分: 5 (Based on 1 Review.)

5 星
100%
4 星
0%
3 星
0%
2 星
0%
1 星
0%

Have you used Pentylenetetrazole?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Use of pentylenetetrazole as GABA-A receptor antagonist.
By Anonymous on 08/31/2019
分析类型： Ex Vivo
种属： Mouse
细胞系/组织： Cerebellum

Pentylenetetrazole was used for pharmacological isolation of glycine receptors response as a GABA-A receptor antagonist with low or no affinity to glycine receptor (GlyR). Clear GlyR single-channel openings with characteristic conductance states were obtained. Figure: recording of GlyR single-channel openings with 1 mM pentylenetetrazole in perfusion solution.

review image

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.