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说明： Peptide inhibitor of GluA2 subunit binding to PICK1
生物活性 for pep2-AVKI
pep2-AVKI is an inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluA2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluA2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression (LTD).
技术数据 for pep2-AVKI
| 分子量 | 1268.47 |
| 公式 | C60H93N13O17 |
| 序列 | YNVYGIEAVKI |
| 储存 | Desiccate at -20°C |
| CAS Number | 1315378-69-8 |
| PubChem ID | 90479810 |
| InChI Key | SODUKHPKIVEQLX-OCXIBOJYSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for pep2-AVKI
参考文献 for pep2-AVKI
参考文献是支持产品生物活性的出版物。
Daw et al (2000) PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron 28 873 PMID: 11163273
Hanley et al (2002) NSF ATPase and α-/β-SNAPs disassemble the AMPA receptor-PICK1 complex. Neuron 34 53 PMID: 11931741
Kim et al (2001) Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Proc.Natl.Acad.Sci.U.S.A. 98 11725 PMID: 11573007
Li et al (1999) AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses. Nat.Neurosci. 2 972 PMID: 10526335
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关键词: pep2-AVKI, pep2-AVKI supplier, Peptide, inhibitors, inhibits, GluR2, subunit, binding, PICK1, Glutamate, AMPA, Receptors, iGluR, Ionotropic, GluA2, 1600, Tocris Bioscience
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