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说明： Allosteric potentiator of AMPA receptor desensitization
化学名： 2-[2,6-Difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]acetamide
纯度： ≥99% (HPLC)
生物活性 for PEPA
Novel allosteric potentiator of AMPA receptor desensitization. Slows the rate of onset of desensitization and potentiates steady-state equilibrium currents induced by glutamate with subunit (GluA3/4 > GluA1) and splice variant (flop > flip) selectivity. Ameliorates post-ischemic memory impairment in rats following i.v. administration.
技术数据 for PEPA
| 分子量 | 402.44 |
| 公式 | C16H16F2N2O4S2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 141286-78-4 |
| PubChem ID | 6603828 |
| InChI Key | GTACSIONMHMRPD-UHFFFAOYSA-N |
| Smiles | FC1=CC(SCCNS(C2=CC=CC=C2)(=O)=O)=CC(F)=C1OCC(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PEPA
参考文献 for PEPA
参考文献是支持产品生物活性的出版物。
Sekiguchi et al (1997) A novel allosteric potentiator of AMPA receptors: 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyacetamide. J.Neurosci. 17 5760 PMID: 9221774
Sekiguchi et al (2002) A desensitization-selective potentiator of AMPA-type glutamate receptors. Br.J.Pharmacol. 136 1033 PMID: 12145103
Sekiguchi et al (2001) The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment. Neuroreport 12 2974
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关键词: PEPA, PEPA supplier, Allosteric, potentiator, AMPA, receptor, desensitization, desensitisation, Glutamate, Receptors, iGluR, Ionotropic, 2929, Tocris Bioscience
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