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PF 06281355

Cat. No. 6004 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective myeloperoxidase (MPO) inhibitor
化学名： 6-(2,5-Dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-1(2H)-pyrimidineacetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PF 06281355

PF 06281355 is a selective myeloperoxidase (MPO) inhibitor (IC50 = 1.5 μM in LPS-stimulated human whole blood). Selective for MPO over a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. Inhibits MPO activity in peritoneal lavage and plasma in a murine peritonitis model. Also reduces lung edema in a murine pulmonary immune complex vasculitis model. Orally bioavailable.

许可信息

Sold for research purposes under agreement from Pfizer Inc

技术数据 for PF 06281355

分子量 321.35
公式 C14H15N3O4S
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 1435467-38-1
PubChem ID 71568997
InChI Key LJBUZOGABRDGBR-UHFFFAOYSA-N
Smiles COC1=CC(C2=CC(NC(N2CC(N)=O)=S)=O)=C(C=C1)OC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PF 06281355

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 6.43 20 温和加热

制备储备液 for PF 06281355

以下数据基于产品分子量 321.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 15.56 mL 77.8 mL 155.59 mL
1 mM 3.11 mL 15.56 mL 31.12 mL
2 mM 1.56 mL 7.78 mL 15.56 mL
10 mM 0.31 mL 1.56 mL 3.11 mL

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参考文献 for PF 06281355

参考文献是支持产品生物活性的出版物。

Zheng et al (2015) PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis. J.Pharmacol.Exp.Ther. 353 288 PMID: 25698787

Ruggeri et al (2015) Discovery of 2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A highly selective mechanism-based myeloperoxidase inhibitor for the treatment of cardiovascular diseases. J.Med.Chem. 58 8513 PMID: 26509551

If you know of a relevant reference for PF 06281355, please let us know.

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关键词: PF 06281355, PF 06281355 supplier, PF06281355, myeloperoxidase, inhibitors, inhibits, selective, orally, bioavailable, vasculitis, Other, Oxygenases/Oxidases, 6004, Tocris Bioscience

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