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Submit ReviewPF 06447475
说明： Potent LRRK2 inhibitor; neuroprotective
化学名： 3-[4-(4-Morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile
纯度： ≥98% (HPLC)
生物活性 for PF 06447475
Potent LRRK2 inhibitor (IC50 = 3 nM). Attenuates α-synuclein-induced dopaminergic neurodegeneration and neuroinflammation in G2019S-LRRK2 expressing rats. Also neuroprotective in wild type rats. Brain penetrant.
许可信息
Sold for research purposes under agreement from Pfizer Inc
技术数据 for PF 06447475
| 分子量 | 305.33 |
| 公式 | C17H15N5O |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1527473-33-1 |
| PubChem ID | 72706840 |
| InChI Key | BHTWDJBVZQBRKP-UHFFFAOYSA-N |
| Smiles | N#CC1=CC(C3=CNC2=NC=NC(N4CCOCC4)=C23)=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PF 06447475
参考文献 for PF 06447475
参考文献是支持产品生物活性的出版物。
Daher et al (2015) Leucine-rich repeat kinase 2 (LRRK2) pharmacological inhibition abates α-synuclein gene-induced neurodegeneration. J.Biol.Chem. 290 19433 PMID: 26078453
Henderson et al (2015) Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J.Med.Chem. 58 419 PMID: 25353650
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关键词: PF 06447475, PF 06447475 supplier, PF06447475, potent, LRRK2, inhibitors, inhibits, neurodegeneration, neuroinflammation, brain, penetrant, 5716, Tocris Bioscience
1 篇 PF 06447475 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PF 06447475 的部分引用包括：
Mir et al (2018) The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human. Biochem J 475 1861 PMID: 29743203
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.