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说明： Positive allosteric modulator of AMPA receptors
化学名： N-[(3R,4S)-3-[4-(5-cyano-2-thienyl)phenyl]tetrahydro-2H-pyran-4-yl]-2-propanesulfonamide
纯度： ≥98% (HPLC)
生物活性 for PF 4778574
Positive allosteric modulator of AMPA receptors (Ki = 85 nM). Prevents ketamine-induced working memory impairments. Brain penetrant.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for PF 4778574
| 分子量 | 390.52 |
| 公式 | C19H22N2O3S2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1219633-99-4 |
| PubChem ID | 44462786 |
| InChI Key | FFAGHPLLBXWCSF-MSOLQXFVSA-N |
| Smiles | O=S(N[C@H]1CCOC[C@@H]1[C@]2=CC=C(C3=CC=C(C#N)S3)C=C2)(C(C)C)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PF 4778574
参考文献 for PF 4778574
参考文献是支持产品生物活性的出版物。
Roberts et al (2010) Prevention of KA-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction. Behav.Brain Res. 212 41 PMID: 20347881
Doran et al (2012) An evaluation of using rat-derived single-dose neuropharmacokinetic parameters to project accurately large animal unbound brain drug concentrations. Drug Metab.Dispos. 40 2162 PMID: 22899853
Shaffer et al (2013) Positive allosteric modulation of AMPA receptors from efficacy to toxicity: the interspecies exposure-response continuum of the novel potentiator PF-4778574. J.Pharmacol.Exp.Ther. 347 212 PMID: 23899905
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