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PF 4981517

Cat. No. 4252 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4252 has been discontinued.

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说明： Selective CYP3A4 inhibitor
化学名： (1-Methyl-3-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-4-[(3S)-3-piperidin-1-ylpyrrolidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine)
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for PF 4981517

PF 4981517 is a potent and selective inhibitor of CYP3A4 (IC50 values are 0.03, 17 and 70 μM for CYP3A4, CYP3A5 and CYP3A7 respectively).

许可信息

Sold for research purposes under agreement from Pfizer Inc.

技术数据 for PF 4981517

分子量 456.59
公式 C26H32N8
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1390637-82-7
PubChem ID 71315139
InChI Key WDWIMDKOXZZYHH-FQEVSTJZSA-N
Smiles CN1N=C(C5=C(C6=CC=C(C)C=C6)N(C)N=C5)C2=C1N=CN=C2N3C[C@@H](N4CCCCC4)CC3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for PF 4981517

参考文献是支持产品生物活性的出版物。

Walsky et al (2012) Selective mechanism-based inactivation of cytochrome P4503A4 by cyp3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of cytochrome P4503A4 versus P4503A5 in the metabolism of drugs. Am.Soc.Pharmacol.Exp.Ther. Epub ahead of print

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关键词: PF 4981517, PF 4981517 supplier, pfizer, PF4981517, selective, inhibitors, inhibits, cyp3a4, cytochrome, p4503A4, cyp3cide, Cytochrome, P450, 4252, Tocris Bioscience

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