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Submit ReviewPF 9184
说明： Potent microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor
化学名： N-[3',4'-Dichloro(1,1'-biphenyl)-yl]-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
纯度： ≥98% (HPLC)
生物活性 for PF 9184
PF 9184 is a potent microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor (IC50 values are 16.5 and 1080 nM for human and rat mPGES-1, respectively). Exhibits >6500-fold selectivity for mPGES-1 over COX-1 and COX-2. Inhibits IL-1β-induced PGE2 synthesis in vitro.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for PF 9184
| 分子量 | 461.32 |
| 公式 | C21H14Cl2N2O4S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1221971-47-6 |
| PubChem ID | 54728414 |
| InChI Key | VGACSWBJQLLJFB-UHFFFAOYSA-N |
| Smiles | OC2=C(C(NC3=CC=C(C4=CC=C(Cl)C(Cl)=C4)C=C3)=O)NS(C1=CC=CC=C12)(=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PF 9184
参考文献 for PF 9184
参考文献是支持产品生物活性的出版物。
Mbalaviele et al (2010) Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor. Biochem.Pharmacol. 79 1445 PMID: 20067770
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关键词: PF 9184, PF 9184 supplier, PF9184, potent, microsomal, prostaglandins-E, synthases, mPGES-1, inhibitors, inhibits, Other, Synthases/Synthetases, 5917, Tocris Bioscience
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