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Submit ReviewPF 998425
说明： Non-steroidal androgen receptor antagonist
化学名： 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile
纯度： ≥98% (HPLC)
生物活性 for PF 998425
Selective non-steroidal androgen receptor (AR) antagonist (IC50 values are 26 nM and 90 nM in AR binding assays and cellular assays respectively). Displays low affinity for progesterone receptor (IC50 > 10 μM). Active in vivo.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for PF 998425
| 分子量 | 269.26 |
| 公式 | C14H14F3NO |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1076225-27-8 |
| PubChem ID | 25093231 |
| InChI Key | MENRRRXHFQYXDW-DGCLKSJQSA-N |
| Smiles | O[C@H](CCCC2)[C@H]2[C@]1=CC(C(F)(F)F)=C(C#N)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PF 998425
参考文献 for PF 998425
参考文献是支持产品生物活性的出版物。
Li et al (2008) Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. J.Med.Chem. 51 7010 PMID: 18921992
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关键词: PF 998425, PF 998425 supplier, selective, nonsteroidal, androgen, receptors, antagonists, PF998425, Pfizer, Androgen, Receptor, 3923, Tocris Bioscience
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