[(pF)Phe⁴]Nociceptin(1-13)NH₂

Name: [(pF)Phe 4 ]Nociceptin(1-13)NH 2
Brand: Tocris Bioscience
SKU: 1566

Cat. No. 1566 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1566 has been discontinued.

View all NOP Receptors products.

说明： Potent, selective nociceptin receptor agonist

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for [(pF)Phe⁴]Nociceptin(1-13)NH₂

[(pF)Phe⁴]Nociceptin(1-13)NH₂ is a highly potent and selective nociceptin/orphanin FQ receptor (OP₄) agonist peptide (pK_i = 10.68; pEC₅₀ = 9.80). Displays > 8000-fold selectivity over δ, κ, and μ opioid receptors and has relatively long lasting pronociceptive, hypotensive, negative inotropic and feeding stimulation effects in vivo.

技术数据 for [(pF)Phe⁴]Nociceptin(1-13)NH₂

分子量	1399.6
公式	C₆₁H₉₉FN₂₂O₁₅
序列	FGGFTGARKSARK (Modifications: Phe-4 = p-fluoro-Phe, Lys-14 = C-terminal amide)
储存	Desiccate at -20°C
CAS Number	380620-88-2
PubChem ID	10260917
InChI Key	OGKNRWXOEHEYOV-QHYQKCGXSA-N
Smiles	[H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=C(F)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for [(pF)Phe⁴]Nociceptin(1-13)NH₂

分析证书/产品说明书

化学品安全技术说明书

参考文献 for [(pF)Phe⁴]Nociceptin(1-13)NH₂

参考文献是支持产品生物活性的出版物。

Bigoni et al (2002) Pharmacological characterisation of [(pX)Phe⁴]nociceptin(1-13)amide analogues. 1. In vitro studies. Naunyn Schmiedebergs Arch.Pharmacol. 365 442 PMID: 12070757

Guerrini et al (2001) Structure-activity studies of the Phe⁴ residue of nociceptin(1-13)-NH₂: Identification of highly potent agonists of the nociceptin/orphanin FQ receptor. J.Med.Chem. 44 3956 PMID: 11689082

Rizzi et al (2002) Pharmacological characterisation of [(pX)Phe⁴]nociceptin(1-13)amide analogues. 2. In vivo studies. Naunyn Schmiedebergs Arch.Pharmacol. 365 450 PMID: 12070758

按标靶查看相关产品

按产品操作查看相关产品

查看全部 NOP Receptor Agonists

关键词: [(pF)Phe4]Nociceptin(1-13)NH2, [(pF)Phe4]Nociceptin(1-13)NH2 supplier, Potent, selective, nociceptin, receptor, agonists, Receptors, ORL1, OP4, NOP, Opioids, 1566, Tocris Bioscience

篇 [(pF)Phe⁴]Nociceptin(1-13)NH₂ 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 [(pF)Phe⁴]Nociceptin(1-13)NH₂ 的引用文献。