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PG 01

Cat. No. 3943 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3943 has been discontinued.

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说明： CFTR potentiator; corrects F508del-CFTR conductance defect
化学名： N-Methyl-N-[2-[[4-(1-Methylethyl)phenyl]amino]-2-1H-indole-3-acetamide
纯度： ≥98% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for PG 01

Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. Corrects gating defects of CFTR mutants such as ΔF508 (Ka = 0.3 μM), E193K and G970R (Kd values are 0.22 μM and 0.45 μM respectively). Increases ΔF508-CFTR Cl- currents in the presence of forskolin; displays no effect on Ca2+-activated Cl- current.

技术数据 for PG 01

分子量 439.55
公式 C28H29N3O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 853138-65-5
PubChem ID 4695397
InChI Key PQAYCXMQTUEDRD-UHFFFAOYSA-N
Smiles O=C(C(C2=CC=CC=C2)N(C)C(CC3=CNC4=C3C=CC=C4)=O)NC1=CC=C(C(C)C)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for PG 01

参考文献是支持产品生物活性的出版物。

Pedemonte et al (2005) Phenylglycine and sulphonamide correctors of defective DF508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating. Mol.Pharmacol. 67 1797 PMID: 15722457

Caputo et al (2009) Mutation-specific potency and efficacy of cystic fibrosis transmembrane conductance regulator chloride channel potentiators. J.Pharmacol.Exp.Ther. 330 783 PMID: 19491324

Pedemonte et al (2010) Influence of cell background on pharmacological rescue of mutant CFTR. Am.J.Physiol.Cell Physiol 298 C866 PMID: 20053923

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关键词: PG 01, PG 01 supplier, PG01, CTFR, mutant, potentiators, cystic, fibrosis, transmembrane, conductance, channels, CFTR, chloride, Cl-, pharmacochaperones, 3943, Tocris Bioscience

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