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Submit ReviewPhenyl-glutarimide 4'-oxyacetic acid
说明： Functionalized cereblon ligand for PROTAC development
化学名： 2-(4-(2,6-Dioxopiperidin-3-yl)phenoxy)acetic acid
纯度： ≥95% (HPLC)
生物活性
Phenyl-glutarimide 4'-oxyacetic acid is a carboxylic acid-functionalized cereblon ligand that can be used for PROTAC® Degrader development. The compound can be used to develop PG-PROTACs that exhibit improved stability to hydrolysis and potency compared with PROTACs synthesized using IMiD (immunomodulatory imide drug) analogs
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines
This product is provided for use in onward chemistry. Suitable solvents can be used.
技术数据
| 分子量 | 263.25 |
| 公式 | C13H13NO5 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 2782024-58-0 |
| InChI Key | AJINEEJVZAYBCQ-UHFFFAOYSA-N |
| Smiles | O=C(N1)CCC(C2=CC=C(C=C2)OCC(O)=O)C1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书
参考文献
参考文献是支持产品生物活性的出版物。
Min et al (2021) Phenyl-glutarimides: alternative cereblon binders for the design of PROTACs. Angew.Chem.Int.Ed. 60 26663 PMID: 34614283
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia