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Phenyl-glutarimide 4'-piperazine

Cat. No. 7729 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Piperazine-functionalized cereblon ligand for PROTAC development
化学名： 3-[4-(1-Piperazinyl)phenyl]-2,6-piperidinedione dihydrochloride
纯度： ≥95% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for Phenyl-glutarimide 4'-piperazine

Phenyl-glutarimide 4'-piperazine is a piperazine-functionalized cereblon ligand that can be used for PROTAC® Degrader development. The compound can be used to develop PG-PROTACs that exhibit improved stability to hydrolysis and potency compared with PROTACs synthesized using IMiD (immunomodulatory imide drug) analogs.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines for Phenyl-glutarimide 4'-piperazine

This product is provided for use in onward chemistry. Suitable solvents can be used.

技术数据 for Phenyl-glutarimide 4'-piperazine

分子量 346.25
公式 C15H19N3O2.2HCl
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2902651-89-0
InChI Key DUZCAOXBUQOLHN-UHFFFAOYSA-N
Smiles O=C1CCC(C2=CC=C(N3CCNCC3)C=C2)C(N1)=O.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Phenyl-glutarimide 4'-piperazine

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Phenyl-glutarimide 4'-piperazine

参考文献是支持产品生物活性的出版物。

Min et al (2021) Phenyl-glutarimides: alternative cereblon binders for the design of PROTACs. Angew.Chem.Int.Ed. 60 26663 PMID: 34614283

Alcock et al (2022) Development of potent and selective Janus kinase 2/3 directing PG-PROTACs. ACS.Med.Chem.Lett. 13 475 PMID: 35300081

If you know of a relevant reference for Phenyl-glutarimide 4'-piperazine, please let us know.

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia