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Submit ReviewPhilanthotoxin 74
说明： GluA1 and GluA3 selective AMPA antagonist
别名： PhTx-74
化学名： (S)-N-[7-[(4-Aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]benzenepropanamide dihydrochloride
纯度： ≥98% (HPLC)
生物活性 for Philanthotoxin 74
Philanthotoxin 74 is an AMPA receptor antagonist. Non-selective homomeric GluA3 and GluA1 receptor antagonist (IC50 values are 263 and 296 nM respectively). Inhibits homomeric GluA3 and GluA1 with a 100-fold greater potency than heteromeric GluA1/2 and GluA2/3 receptors.
技术数据 for Philanthotoxin 74
| 分子量 | 507.54 |
| 公式 | C24H42N4O3.2HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1227301-51-0 |
| PubChem ID | 46213501 |
| InChI Key | HWTJQQMIKVJWLH-IKXQUJFKSA-N |
| Smiles | OC1=CC=C(C[C@H](NC(CCC)=O)C(NCCCCCCCNCCCCN)=O)C=C1.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Philanthotoxin 74
参考文献 for Philanthotoxin 74
参考文献是支持产品生物活性的出版物。
Nilsen and England (2007) A subtype-selective, use-dependent inhibitor of native AMPA receptors. J.Am.Chem.Soc. 129 4902 PMID: 17391037
Poulsen et al (2013) Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors. Mol.Pharmacol. 85 261 PMID: 24220009
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关键词: Philanthotoxin 74, Philanthotoxin 74 supplier, GluR1/2, selective, AMPA, antagonists, Glutamate, Receptors, iGluR, Ionotropic, Philanthotoxin74, PhTx74, homomeric, GluR3, GluR1, GluR2/3, GluA1, GluA2, GluA3, PhTx-74, 2770, Tocris Bioscience
2 篇 Philanthotoxin 74 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Philanthotoxin 74 的部分引用包括：
Zhao et al (2018) Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region. iScience 6 138 PMID: 30240608
Kim and Ziff (2014) Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors. PLoS Biol 12 e1001900 PMID: 24983627
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