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说明： Functionalized photoswitchable cereblon ligand for Degraders
化学名： (E)-2-(4-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)diazenyl)-2,6-dimethoxyphenoxy)acetic acid
纯度： ≥95% (HPLC)
生物活性 for Photo-lenalidomide-acid
Photo-lenalidomide-acid is a functionalized cereblon ligand containing a dimethoxy azo-benzene photoswitch; for use as a precursor to photoswitchable Degraders (PHOTACs). Photo-lenalidomide-acid is supplied with a carboxylic acid functional handle for ready conjugation to a linker/target protein ligand. Part of a range of functionalized tool molecules for Degrader R&D.
Usage Guidelines for Photo-lenalidomide-acid
This product is provided for use in onward chemistry. Suitable solvents can be used.
技术数据 for Photo-lenalidomide-acid
| 分子量 | 482.45 |
| 公式 | C23H22N4O8 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 2363154-39-4 |
| InChI Key | CGLOIOJVUYAUAC-OCEACIFDSA-N |
| Smiles | COC1=CC(/N=N/C2=C3CN(C(C3=CC=C2)=O)C4CCC(NC4=O)=O)=CC(OC)=C1OCC(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Photo-lenalidomide-acid
参考文献 for Photo-lenalidomide-acid
参考文献是支持产品生物活性的出版物。
Reynders et al (2020) PHOTACs enable optical control of protein degradation. Sci.Adv. 6 eaay5064 PMID: 32128406
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关键词: Photo-lenalidomide-acid, Photo-lenalidomide-acid supplier, PROTACs, degraders, building, blocks, photoswitchable, carboxylic, acid, functionalized, cereblon, e3, ligase, ligand, targeted, protein, degradation, tpd, Functionalized, E3, Ligase, Ligands, 7328, Tocris Bioscience
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Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia