主页 / 药理学 / Enzymes / Reductases / Dihydrofolate Reductase / Dihydrofolate Reductase Inhibitors / Phototrexate

Phototrexate

Cat. No. 7362 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Photoswitchable inhibitor of human dihydrofolate reductase
化学名： N-[4-[(1E)-2-(2,4-Diamino-6-quinazolinyl)diazenyl]benzoyl]-L-glutamic acid
纯度： ≥95% (HPLC)
说明书
引用文献
评论
生物活性 Scientific Data 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Phototrexate

Phototrexate is a photoswitchable potent inhibitor of human dihydrofolate reductase (DHFR). Phototrexate is a photochromic analog of Methotrexate (Cat. No. 1230). Antifolate activity is switched on (cis-Phototrexate) by UVA (375 nm) light; it can be switched off (trans-Phototrexate) by blue or white light and by thermal relaxation in the dark. cis-Phototrexate (IC50 = 6 nM) significantly reduces the viability of HeLa cells compared with trans-Phototrexate (IC50 = 34 μM).

Scientific Data

Photoswitching activity of Phototrexate View Larger

Photoswitching activity of Phototrexate Antifolate activity is switched on (cis-Phototrexate) by UVA (375 nm) light; it can be switched off (trans-Phototrexate) by blue or white light and by thermal relaxation in the dark.

许可信息

Sold with permission of IBEC.

技术数据 for Phototrexate

分子量 437.42
公式 C20H19N7O5
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2268033-83-4
PubChem ID 142608675
InChI Key IODLJULYGHWOLC-HIUCBWPRSA-N
Smiles NC1=NC2=C(C(N)=N1)C=C(/N=N/C3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C3)C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Phototrexate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 1.75 4

制备储备液 for Phototrexate

以下数据基于产品分子量 437.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.04 mM 57.15 mL 285.77 mL 571.53 mL
0.2 mM 11.43 mL 57.15 mL 114.31 mL
0.4 mM 5.72 mL 28.58 mL 57.15 mL
2 mM 1.14 mL 5.72 mL 11.43 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for Phototrexate

参考文献是支持产品生物活性的出版物。

Matera et al (2018) Photoswitchable antimetabolite for targeted photoactivated chemotherapy. J.Am.Chem.Soc. 140 15764 PMID: 30346152

Mashita et al (2019) Light-wavelength-based quantitative control of dihydrofolate reductase activity by using a photochromic isostere of an inhibitor. Chembiochem. 20 1382 PMID: 30656808

If you know of a relevant reference for Phototrexate, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Dihydrofolate Reductase Inhibitors

关键词: Phototrexate, Phototrexate supplier, photoswitchable, inhibitors, inhibits, potent, dihydrofolate, reductase, DHFR, methotrexate, analog, analogue, Dihydrofolate, Reductase, Photoswitchable, Ligands, 7362, Tocris Bioscience

篇 Phototrexate 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Phototrexate 的引用文献。 您是否知道使用了 Tocris Phototrexate 的优秀论文？ 请告知我们.

Phototrexate 的评论

目前没有该产品的评论。 Be the first to review Phototrexate and earn rewards!

Have you used Phototrexate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review